Title : Design, synthesis, molecular docking and anticancer evaluations of 5-benzylidenethiazolidine-2,4-dione derivatives targeting VEGFR-2 enzyme.

Pub. Date : 2020 Sep

PMID : 32653608






1 Functional Relationships(s)
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1 Among them, compounds 8f was found to be the most potent derivative that inhibited VEGFR-2 at IC50 value of 0.22 +- 0.02 microM, which is nearly the half as that of sorafenib IC50 value (0.10 +- 0.02 microM). Sorafenib kinase insert domain receptor Homo sapiens