Pub. Date : 2020 Jul 6
PMID : 32632306
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Spermidine activates RIP1 deubiquitination to inhibit TNF-alpha-induced NF-kappaB/p65 signaling pathway in osteoarthritis. | Spermidine | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 2 | In terms of the mechanism, 9 muM spermidine did not affect the viability, proliferation, cell cycle and apoptosis of H-FLS, and exerted inhibitory effects by activating CYLD-mediated RIP1 deubiquitination on TNF-alpha-induced NF-kappaB/p65 signaling in H-FLS. | Spermidine | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 3 | From these data, we can conclude that spermidine attenuates OA progression by the inhibition of TNF-alpha-induced NF-kappaB pathway via the deubiquitination of RIP1 in FLS. | Spermidine | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |