Title : Ibudilast, a Phosphodiesterase Inhibitor and Toll-Like Receptor-4 Antagonist, Improves Hemorrhagic Shock and Reperfusion-Induced Left Ventricular Dysfunction by Reducing Myocardial Tumor Necrosis Factor α.

Pub. Date : 2020 Jul - Aug

PMID : 32631581






2 Functional Relationships(s)
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1 Ibudilast, a Phosphodiesterase Inhibitor and Toll-Like Receptor-4 Antagonist, Improves Hemorrhagic Shock and Reperfusion-Induced Left Ventricular Dysfunction by Reducing Myocardial Tumor Necrosis Factor alpha. ibudilast tumor necrosis factor Rattus norvegicus
2 CONCLUSIONS: Ibudilast pretreatment reduced myocardial TLR4 expression, decreased MDA and TNF-alpha levels, and protected against HSR-induced decrease in LV contractility, prolonged LV relaxation time, and increased diastolic stiffness. ibudilast tumor necrosis factor Rattus norvegicus