Pub. Date : 1988 Oct 25
PMID : 3262616
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The metabolism of ddAdo in the kinase-deficient mutants was found to be unchanged by comparison with that in parental cells; however, the inhibition of ddAdo deamination to 2",3"-dideoxyinosine (ddIno) by the adenosine deaminase inhibitor, 2"-deoxycoformycin, reduced ddAdo nucleotide formation in deoxycytidine kinase-deficient, adenosine kinase-deficient, and doubly kinase-deficient mutants by 42, 54, and 80%, respectively. | Didanosine | deoxycytidine kinase | Homo sapiens |
| 2 | The metabolism of ddAdo in the kinase-deficient mutants was found to be unchanged by comparison with that in parental cells; however, the inhibition of ddAdo deamination to 2",3"-dideoxyinosine (ddIno) by the adenosine deaminase inhibitor, 2"-deoxycoformycin, reduced ddAdo nucleotide formation in deoxycytidine kinase-deficient, adenosine kinase-deficient, and doubly kinase-deficient mutants by 42, 54, and 80%, respectively. | Didanosine | deoxycytidine kinase | Homo sapiens |