Pub. Date : 2020 Jul 3
PMID : 32618269
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chemical and structural investigation of the paroxetine-human serotonin transporter complex. | Paroxetine | solute carrier family 6 member 4 | Homo sapiens |
| 2 | To address these concerns, we determined the structures of N72/ C13 and ts2-inactive SERT bound to paroxetine analogues using single-particle cryo-EM and x-ray crystallography, respectively. | Paroxetine | solute carrier family 6 member 4 | Homo sapiens |
| 3 | These studies provide mutually consistent insights into how paroxetine and its analogues bind to the central substrate-binding site of SERT, stabilize the outward-open conformation, and inhibit serotonin transport. | Paroxetine | solute carrier family 6 member 4 | Homo sapiens |