Protein Name solute carrier family 6 member 4
Organism Homo sapiens
Gene ID 6532
Gene Symbol


UniProt P31645 (SC6A4_HUMAN), B2R7Y7 (B2R7Y7_HUMAN)
Relationships Total Number of functionally related compound(s) : 897
Total Number of Articles : 1891

solute carrier family 6 member 4

Gene Summary

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression. [provided by RefSeq, May 2019]

  • sodium-dependent serotonin transporter
  • 5-hydroxytryptamine (serotonin) transporter
  • 5HT transporter
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