Title : Reciprocal regulation between GCN2 (eIF2AK4) and PERK (eIF2AK3) through the JNK-FOXO3 axis to modulate cancer drug resistance and clonal survival.

Pub. Date : 2020 Sep 15

PMID : 32615282






1 Functional Relationships(s)
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1 Conversely, PERK-inactivation using GSK2606414 also induces an induction in GCN2 expression and activity also associated with JNK. 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine mitogen-activated protein kinase 8 Homo sapiens