Title : The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation.

Pub. Date : 2020 Jun 29

PMID : 32600307






1 Functional Relationships(s)
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1 The aim of this study was to determine whether 3-(2,4 dimethoxy-benzylidene)-anabaseine dihydrochloride, GTS-21, an alpha7nAChR partial agonist, inhibits hyperoxia-induced HMGB1 accumulation in the airways and circulation, and consequently attenuates inflammatory lung injury. 3-(2,4-dimethoxybenzylidene)anabaseine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus