Title : The development of a targeted and more potent, anti-Inflammatory derivative of colchicine: Implications for gout.

Pub. Date : 2020 Oct

PMID : 32598947






1 Functional Relationships(s)
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1 The ability of the colchicine analogues with the predicted highest affinity for betaVI-tubulin to dampen neutrophil responses to MSU was determined with in vitro assays that measure MSU-induced production of ROS, release of IL-1 and IL-8, and the increase in the concentration of cytoplasmic calcium. Colchicine interleukin 1 alpha Homo sapiens