Title : Structure based design of inhibitory peptides targeting ornithine decarboxylase dimeric interface and in vitro validation in human retinoblastoma Y79 cells.

Pub. Date : 2021 Sep

PMID : 32597331






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Polyamine synthesis in human cells is initiated by catalytic action of Ornithine decarboxylase (ODC) on Ornithine. Polyamines ornithine decarboxylase 1 Homo sapiens
2 Polyamine synthesis in human cells is initiated by catalytic action of Ornithine decarboxylase (ODC) on Ornithine. Polyamines ornithine decarboxylase 1 Homo sapiens
3 On collective analysis, Peptide3 (Pep 3) and Peptide4 (Pep 4) were found to be potentially targeting ODC, as these peptides showed significant decrease in intracellular polyamine levels, cell adhesion and cell cycle perturbation in Y79 cells. Polyamines ornithine decarboxylase 1 Homo sapiens