Title : A small-molecule ARTS mimetic promotes apoptosis through degradation of both XIAP and Bcl-2.

Pub. Date : 2020 Jun 25

PMID : 32587235






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Like ARTS, A4 stimulated poly-ubiquitylation and UPS-mediated degradation of XIAP and Bcl-2, but not cIAP1, resulting in caspase-9 and -3 activation and apoptosis. a4 BCL2 apoptosis regulator Homo sapiens