Title : Phloroglucinol Attenuates Ultraviolet B-Induced 8-Oxoguanine Formation in Human HaCaT Keratinocytes through Akt and Erk-Mediated Nrf2/Ogg1 Signaling Pathways.

Pub. Date : 2021 Jan 1

PMID : 32587122






5 Functional Relationships(s)
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1 Phloroglucinol Attenuates Ultraviolet B-Induced 8-Oxoguanine Formation in Human HaCaT Keratinocytes through Akt and ErkMediated Nrf2/Ogg1 Signaling Pathways. Phloroglucinol NFE2 like bZIP transcription factor 2 Homo sapiens
2 Phloroglucinol also enhanced the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) as well as Nrf2 binding to an antioxidant response element located in the Ogg1 gene promoter. Phloroglucinol NFE2 like bZIP transcription factor 2 Homo sapiens
3 Phloroglucinol also enhanced the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) as well as Nrf2 binding to an antioxidant response element located in the Ogg1 gene promoter. Phloroglucinol NFE2 like bZIP transcription factor 2 Homo sapiens
4 Phloroglucinol also enhanced the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) as well as Nrf2 binding to an antioxidant response element located in the Ogg1 gene promoter. Phloroglucinol NFE2 like bZIP transcription factor 2 Homo sapiens
5 These results indicated that phloroglucinol attenuated UVB-induced 8-oxoG formation in keratinocytes via an Akt/Erk-dependent, Nrf2/Ogg1-mediated signaling pathway. Phloroglucinol NFE2 like bZIP transcription factor 2 Homo sapiens