Title : Sequential bortezomib and temozolomide treatment promotes immunological responses in glioblastoma patients with positive clinical outcomes: A phase 1B study.

Pub. Date : 2020 Sep

PMID : 32578964






1 Functional Relationships(s)
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1 Patients segregated a priori into three groups, where group 1 displayed stable clinical symptoms and/or slower magnetic resonance imaging radiological progression, expanded CD4+ effector T-cells that attenuated cytotoxic T-lymphocyte associated protein-4 and PD-1 expression and secreted interferon gamma and tumor necrosis factor alpha in situ and ex vivo upon stimulation with PMA/ionomycin. Ionomycin CD4 molecule Homo sapiens