Pub. Date : 2020 Nov
PMID : 32572277
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Using chemoproteomic platforms, we show that members of the manumycin family of polyketides, which bear multiple potentially reactive sites, target C374 of the putative E3 ligase UBR7 in breast cancer cells, and engage in molecular glue interactions with the neosubstrate tumor-suppressor TP53, leading to p53 transcriptional activation and cell death. | Polyketides | tumor protein p53 | Homo sapiens |
2 | Using chemoproteomic platforms, we show that members of the manumycin family of polyketides, which bear multiple potentially reactive sites, target C374 of the putative E3 ligase UBR7 in breast cancer cells, and engage in molecular glue interactions with the neosubstrate tumor-suppressor TP53, leading to p53 transcriptional activation and cell death. | Polyketides | tumor protein p53 | Homo sapiens |