Title : Cytochrome P450 2E1 should not be neglected for acetaminophen-induced liver injury in metabolic diseases with altered insulin levels or glucose homeostasis.

Pub. Date : 2021 Jan

PMID : 32571750






5 Functional Relationships(s)
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Protein Name
Organism
1 Acetaminophen (APAP) hepatotoxicity is mediated by N-acetyl-p-benzoquinone imine (NAPQI), a highly toxic metabolite generated by cytochrome P450 2E1 (CYP2E1). Acetaminophen cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus
2 Acetaminophen (APAP) hepatotoxicity is mediated by N-acetyl-p-benzoquinone imine (NAPQI), a highly toxic metabolite generated by cytochrome P450 2E1 (CYP2E1). Acetaminophen cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus
3 Acetaminophen (APAP) hepatotoxicity is mediated by N-acetyl-p-benzoquinone imine (NAPQI), a highly toxic metabolite generated by cytochrome P450 2E1 (CYP2E1). Acetaminophen cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus
4 Acetaminophen (APAP) hepatotoxicity is mediated by N-acetyl-p-benzoquinone imine (NAPQI), a highly toxic metabolite generated by cytochrome P450 2E1 (CYP2E1). Acetaminophen cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus
5 Thus, pathological conditions increasing CYP2E1 activity can favour APAP-induced liver injury, which is characterized by massive hepatocellular necrosis and secondary sterile inflammation. Acetaminophen cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus