Title : A library of nucleotide analogues terminate RNA synthesis catalyzed by polymerases of coronaviruses that cause SARS and COVID-19.

Pub. Date : 2020 Aug

PMID : 32562705






1 Functional Relationships(s)
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1 We previously demonstrated that five nucleotide analogues inhibit the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), including the active triphosphate forms of Sofosbuvir, Alovudine, Zidovudine, Tenofovir alafenamide and Emtricitabine. Sofosbuvir ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2