Title : Chiral Discrimination of P-glycoprotein in Parturient Women: Effect of Fluoxetine on Maternal-Fetal Fexofenadine Pharmacokinetics.

Pub. Date : 2020 Jun 17

PMID : 32557079






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Fexofenadine, an in vivo P-gp probe, is an antihistamine drug for seasonal allergic rhinitis and chronic urticaria treatment during pregnancy and it is available as a racemic mixture. fexofenadine ATP binding cassette subfamily B member 1 Homo sapiens
2 CONCLUSIONS: A single oral dose of 40 mg fluoxetine inhibited the intestinal P-gp mediated transport of S-(-)-fexofenadine to a greater extent than R-(+)-fexofenadine in parturient women. fexofenadine ATP binding cassette subfamily B member 1 Homo sapiens