Title : Sodium Butyrate Exacerbates Parkinson's Disease by Aggravating Neuroinflammation and Colonic Inflammation in MPTP-Induced Mice Model.

Pub. Date : 2020 Sep

PMID : 32556930






2 Functional Relationships(s)
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1 In vitro study also confirmed that NaB could significantly exacerbate pro-inflammatory cytokines expression (IL-1beta, 4.11-fold, P < 0.01; IL-18, 3.42-fold, P < 0.01 and iNOS, 2.52-fold, P < 0.05) and NO production (1.55-fold, P < 0.001) in LPS-stimulated BV2 cells. nab interleukin 18 Mus musculus
2 In addition, NaB upregulated the expression of pro-inflammatory cytokines (IL-6, 3.52-fold, P < 0.05; IL-18, 1.72-fold, P < 0.001) and NLRP3 (3.11-fold, P < 0.001) in the colon of PD mice. nab interleukin 18 Mus musculus