Protein Name interleukin 18
Organism Mus musculus
Gene ID 16173
Gene Symbol


UniProt P70380 (IL18_MOUSE), Q2PMY2 (Q2PMY2_MOUSE)
Relationships Total Number of functionally related compound(s) : 473
Total Number of Articles : 615

interleukin 18

Gene Summary

Enables cytokine activity. Involved in lipid homeostasis; positive regulation of cell differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including interleukin-18-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling; and positive regulation of interferon-gamma production. Located in extracellular space. Is expressed in several structures, including back skin; dorsal aorta; gut; lymphatic system; and reproductive system. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18). [provided by Alliance of Genome Resources, Apr 2022]

  • interleukin-18
  • IFN-gamma-inducing factor
  • IL-1 gamma
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