| Protein Name | interleukin 18 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 16173 |
| Gene Symbol | Il18 |
| UniProt | P70380 (IL18_MOUSE), Q2PMY2 (Q2PMY2_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
473
Total Number of Articles : 615 |
Description |
interleukin 18 |
| Gene Summary |
Enables cytokine activity. Involved in several processes, including cholesterol homeostasis; establishment of skin barrier; and positive regulation of cell differentiation. Acts upstream of or within several processes, including natural killer cell mediated cytotoxicity; negative regulation of myoblast differentiation; and positive regulation of type II interferon production. Is active in extracellular space. Is expressed in extraembryonic component; gut; lymphatic system; reproductive system; and trunk. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and liver disease (multiple). Orthologous to human IL18 (interleukin 18). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |