Title : The selective PPAR-delta agonist seladelpar reduces ethanol-induced liver disease by restoring gut barrier function and bile acid homeostasis in mice.

Pub. Date : 2021 Jan

PMID : 32553670






3 Functional Relationships(s)
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1 The selective PPAR-delta agonist seladelpar reduces ethanol-induced liver disease by restoring gut barrier function and bile acid homeostasis in mice. Seladelpar peroxisome proliferator activator receptor delta Mus musculus
2 Here, we evaluated the effect of the selective PPAR-delta agonist seladelpar (MBX-8025) on gut barrier function and bile acid metabolism in a mouse model of ethanol-induced liver disease. Seladelpar peroxisome proliferator activator receptor delta Mus musculus
3 Data from this study demonstrates that seladelpar prevents and treats ethanol-induced liver damage in mice by direct PPARdelta agonism in both the liver and the intestine. Seladelpar peroxisome proliferator activator receptor delta Mus musculus