Title : 3,3'-Diindolylmethane modulates aryl hydrocarbon receptor of esophageal squamous cell carcinoma to reverse epithelial-mesenchymal transition through repressing RhoA/ROCK1-mediated COX2/PGE2 pathway.

Pub. Date : 2020 Jun 16

PMID : 32546278






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Co-IP results showed DIM could modulate AHR to reverse EMT directly through inhibition of interaction between AHR and EGFR (epidermal growth factor receptor) so as to block RhoA/ROCK1-mediated COX2/PGE2 pathway which was connected by NF-kappaB. Dinoprostone epidermal growth factor receptor Homo sapiens
2 Co-IP results showed DIM could modulate AHR to reverse EMT directly through inhibition of interaction between AHR and EGFR (epidermal growth factor receptor) so as to block RhoA/ROCK1-mediated COX2/PGE2 pathway which was connected by NF-kappaB. Dinoprostone epidermal growth factor receptor Homo sapiens