Title : Inhibition of HMGB1 Overcomes Resistance to Radiation and Chemotherapy in Nasopharyngeal Carcinoma.

Pub. Date : 2020

PMID : 32523355






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Deficiency of HMGB1 sensitized wild-type (WT) and resistant NPC cells to IR and cisplatin. Cisplatin high mobility group box 1 Homo sapiens
2 Conclusion: HMGB1 promotes NHEJ via interaction with Ku70 resulting in resistance to IR and cisplatin. Cisplatin high mobility group box 1 Homo sapiens
3 Inhibition of HMGB1 by glycyrrhizin is a potential therapeutic regimen to treat cisplatin and IR resistant NPC patients. Cisplatin high mobility group box 1 Homo sapiens