Title : Shedding-Resistant HIV-1 Envelope Glycoproteins Adopt Downstream Conformations That Remain Responsive to Conformation-Preferring Ligands.

Pub. Date : 2020 Aug 17

PMID : 32522853






1 Functional Relationships(s)
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1 Shedding of gp120, known to severely complicate structural studies, can be prevented by using the uncleaved gp160JR-FL precursor with alterations in the protease cleavage site (R508S/R511S), or by introducing a disulfide bridge between gp120 and gp41 designated "SOS" (A501C/T605C). Disulfides inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens