Title : IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival.

Pub. Date : 2020 Jun

PMID : 32520957






1 Functional Relationships(s)
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1 Here we report that the inositol-requiring enzyme 1 (IRE1alpha) branch of the UPR is directly involved in the polarization of macrophages in vitro and in vivo, including the up-regulation of interleukin 6 (IL-6), IL-23, Arginase1, as well as surface expression of CD86 and programmed death ligand 1 (PD-L1). Inositol endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus