Pub. Date : 2020 Aug 1
PMID : 32516358
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Briefly, that AOP identifies PPARalpha antagonist binding as the molecular initiating event (MIE) leading to a series of key events (KEs) including inhibition of nuclear transactivation for genes controlling lipid metabolism and ketogenesis, inhibition of fatty acid beta-oxidation and ketogenesis dynamics, negative energy budget, and ultimately the adverse outcome (AO) of body-weight loss. | Fatty Acids | peroxisome proliferator activated receptor alpha | Homo sapiens |