Title : Design, synthesis, molecular docking, and anticancer evaluations of 1-benzylquinazoline-2,4(1H,3H)-dione bearing different moieties as VEGFR-2 inhibitors.

Pub. Date : 2020 Aug

PMID : 32510731






1 Functional Relationships(s)
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Protein Name
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1 Compounds 11b, 11e, and 11c potently inhibited VEGFR-2 at IC50 values of 0.12 +- 0.02, 0.12 +- 0.02, and 0.13 +- 0.02 microM, respectively, which are nearly equipotent as sorafenib IC50 value (0.10 +- 0.02 microM). Sorafenib kinase insert domain receptor Homo sapiens