Pub. Date : 2020 Oct
PMID : 32506763
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Further results showed that NaAsO2 increased expression in biomarker of endoplasmic reticulum (ER) stress and activated the protein kinase R-like ER kinase (PERK)-eukaryotic translation initiation 2alpha (eIF2alpha)-activating transcription factor 4 (ATF4) pathway. | sodium arsenite | activating transcription factor 4 | Homo sapiens |
| 2 | Further results showed that NaAsO2 increased expression in biomarker of endoplasmic reticulum (ER) stress and activated the protein kinase R-like ER kinase (PERK)-eukaryotic translation initiation 2alpha (eIF2alpha)-activating transcription factor 4 (ATF4) pathway. | sodium arsenite | activating transcription factor 4 | Homo sapiens |
| 3 | PERK inhibitor and ATF4 siRNA significantly attenuated NaAsO2 -induced CHOP and DR5 expressions. | sodium arsenite | activating transcription factor 4 | Homo sapiens |
| 4 | Taken together, the results indicate that ROS-mediated PERK-eIF2alpha-ATF4 pathway activated by NaAsO2 is the critical upstream event for subsequent apoptosis induction via regulating CHOP-DR5 signaling in L-02 cells when chronic exposure to arsenic, and support that antioxidants might be potential therapeutic agents for preventing or delaying the onset and progress of arsenic-induced hepatotoxicity. | sodium arsenite | activating transcription factor 4 | Homo sapiens |