Title : Role of visfatin in promoting proliferation and invasion of colorectal cancer cells by downregulating SDF-1/CXCR4-mediated miR-140-3p expression.

Pub. Date : 2020 May

PMID : 32495871






3 Functional Relationships(s)
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Protein Name
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1 MiR-140-3p expression was downregulated by treatment with visfatin, and miR-140-3p exerted similar effects to those of visfatin knockdown on the proliferation and invasion of CRC cells. mir-140-3p nicotinamide phosphoribosyltransferase Mus musculus
2 In vivo, visfatin stimulated CRC tumor growth and downregulated miR-140-3p expression, whereas it upregulated SDF-1/CXCR4 expression. mir-140-3p nicotinamide phosphoribosyltransferase Mus musculus
3 CONCLUSIONS: Visfatin promotes CRC progression by downregulating the SDF-1/CXCR4-mediated expression of miR-140-3p both in vitro and in vivo. mir-140-3p nicotinamide phosphoribosyltransferase Mus musculus