Title : RNA Sequencing-Based Identification of Ganglioside GD2-Positive Cancer Phenotype.

Pub. Date : 2020 May 30

PMID : 32486168






2 Functional Relationships(s)
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1 We identified a 2-gene expression signature combining ganglioside synthase genes ST8SIA1 and B4GALNT1 that serves as a more efficient predictor of GD2-positive phenotype (Matthews Correlation Coefficient (MCC) 0.32, 0.88, and 0.98 in three independent comparisons) compared to the individual ganglioside biosynthesis genes (MCC 0.02-0.32, 0.1-0.75, and 0.04-1 for the same independent comparisons). Gangliosides ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 Homo sapiens
2 We identified a 2-gene expression signature combining ganglioside synthase genes ST8SIA1 and B4GALNT1 that serves as a more efficient predictor of GD2-positive phenotype (Matthews Correlation Coefficient (MCC) 0.32, 0.88, and 0.98 in three independent comparisons) compared to the individual ganglioside biosynthesis genes (MCC 0.02-0.32, 0.1-0.75, and 0.04-1 for the same independent comparisons). Gangliosides ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 Homo sapiens