Pub. Date : 2020 Sep 1
PMID : 32485183
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol binds and inhibits transcription factor HIF-1alpha in pancreatic cancer. | Resveratrol | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 2 | Resveratrol was identified as a natural compound with many biological functions, with anti-inflammatory, antioxidant, and anticancer effects that inhibit the proliferation and progression of PC cells caused by HIF-1alpha. | Resveratrol | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 3 | The current investigation explored the binding affinity and ligand efficacy of resveratrol against HIF-1alpha using an in silico approach, and the execution of molecular dynamics simulation (MDS) increased the prediction precision of these outcomes. | Resveratrol | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 4 | This is the first study that provides an in silico characterization of the interaction between resveratrol and HIF-1alpha and its spatial structural arrangements in pancreatic cancer therapy, providing an in-depth analysis of their drug target interactions. | Resveratrol | hypoxia inducible factor 1 subunit alpha | Homo sapiens |