Title : The improvement effect of gastrodin on LPS/GalN-induced fulminant hepatitis via inhibiting inflammation and apoptosis and restoring autophagy.

Pub. Date : 2020 Aug

PMID : 32473572






2 Functional Relationships(s)
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1 Furthermore, GTD treatment could significantly inhibit inflammation-related signaling pathways activated by LPS/GalN, including the suppression of nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) and nuclear factor-kappa B (NF-kappaB) activation. gastrodin NLR family, pyrin domain containing 3 Mus musculus
2 Taken together, our investigation indicated that GTD played an essential role in liver protection by relieving hepatocyte apoptosis and inflammation reaction, which may be closely involved in the inhibition of NLRP3 inflammasome and NF-kappaB activation, regulation of apoptosis-related proteins expression, and the recovery of AMPK/ACC/autophagy. gastrodin NLR family, pyrin domain containing 3 Mus musculus