Pub. Date : 2020 Jul
PMID : 32472575
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ethanol and cannabinoids regulate zebrafish GABAergic neuron development and behavior in a sonic hedgehog and fibroblast growth factor dependent mechanism. | Ethanol | sonic hedgehog signaling molecule a | Danio rerio |
| 2 | BACKGROUND: Ethanol has diverse effects on nervous system development, which includes development and survival of GABAergic neurons in a sonic hedgehog (Shh) and fibroblast growth factor (Fgf)-dependent mechanism. | Ethanol | sonic hedgehog signaling molecule a | Danio rerio |
| 3 | BACKGROUND: Ethanol has diverse effects on nervous system development, which includes development and survival of GABAergic neurons in a sonic hedgehog (Shh) and fibroblast growth factor (Fgf)-dependent mechanism. | Ethanol | sonic hedgehog signaling molecule a | Danio rerio |
| 4 | Cannabinoids also function as inhibitors of Shh signaling, raising the possibility that ethanol and cannabinoids may interact to broadly disrupt neuronal function during brain development. | Ethanol | sonic hedgehog signaling molecule a | Danio rerio |
| 5 | Consistent with the ethanol and cannabinoid effects on Shh signaling, fgf8 mRNA overexpression rescues the ethanol- and cannabinoid-induced decrease in gad1 gene expression and also prevents the changes in behavior induced by ethanol and cannabinoids. | Ethanol | sonic hedgehog signaling molecule a | Danio rerio |
| 6 | CONCLUSIONS: These studies provide evidence that forebrain GABAergic neuron development, and zebrafish risk-taking behavior, are sensitive to both ethanol and cannabinoid exposure in a Shh- and Fgf-dependent mechanism, and provide additional evidence that a signaling pathway involving Shh and Fgf crosstalk is a critical target of ethanol and cannabinoids in FASD. | Ethanol | sonic hedgehog signaling molecule a | Danio rerio |
| 7 | CONCLUSIONS: These studies provide evidence that forebrain GABAergic neuron development, and zebrafish risk-taking behavior, are sensitive to both ethanol and cannabinoid exposure in a Shh- and Fgf-dependent mechanism, and provide additional evidence that a signaling pathway involving Shh and Fgf crosstalk is a critical target of ethanol and cannabinoids in FASD. | Ethanol | sonic hedgehog signaling molecule a | Danio rerio |