PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32472575-0 2020 Ethanol and cannabinoids regulate zebrafish GABAergic neuron development and behavior in a sonic hedgehog and fibroblast growth factor dependent mechanism. Ethanol 0-7 sonic hedgehog signaling molecule a Danio rerio 91-105 32472575-1 2020 BACKGROUND: Ethanol has diverse effects on nervous system development, which includes development and survival of GABAergic neurons in a sonic hedgehog (Shh) and fibroblast growth factor (Fgf)-dependent mechanism. Ethanol 12-19 sonic hedgehog signaling molecule a Danio rerio 137-151 32472575-1 2020 BACKGROUND: Ethanol has diverse effects on nervous system development, which includes development and survival of GABAergic neurons in a sonic hedgehog (Shh) and fibroblast growth factor (Fgf)-dependent mechanism. Ethanol 12-19 sonic hedgehog signaling molecule a Danio rerio 153-156 32472575-2 2020 Cannabinoids also function as inhibitors of Shh signaling, raising the possibility that ethanol and cannabinoids may interact to broadly disrupt neuronal function during brain development. Ethanol 88-95 sonic hedgehog signaling molecule a Danio rerio 44-47 32472575-6 2020 Consistent with the ethanol and cannabinoid effects on Shh signaling, fgf8 mRNA overexpression rescues the ethanol- and cannabinoid-induced decrease in gad1 gene expression and also prevents the changes in behavior induced by ethanol and cannabinoids. Ethanol 20-27 sonic hedgehog signaling molecule a Danio rerio 55-58 32472575-7 2020 CONCLUSIONS: These studies provide evidence that forebrain GABAergic neuron development, and zebrafish risk-taking behavior, are sensitive to both ethanol and cannabinoid exposure in a Shh- and Fgf-dependent mechanism, and provide additional evidence that a signaling pathway involving Shh and Fgf crosstalk is a critical target of ethanol and cannabinoids in FASD. Ethanol 147-154 sonic hedgehog signaling molecule a Danio rerio 185-188 32472575-7 2020 CONCLUSIONS: These studies provide evidence that forebrain GABAergic neuron development, and zebrafish risk-taking behavior, are sensitive to both ethanol and cannabinoid exposure in a Shh- and Fgf-dependent mechanism, and provide additional evidence that a signaling pathway involving Shh and Fgf crosstalk is a critical target of ethanol and cannabinoids in FASD. Ethanol 147-154 sonic hedgehog signaling molecule a Danio rerio 286-289