Pub. Date : 2020 Nov
PMID : 32463566
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Systemic Lupus Erythematosus Activity Affects the Sinusoidal Uptake Transporter OATP1B1 Evaluated by the Pharmacokinetics of Atorvastatin. | Atorvastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 2 | The present study assessed the effect of systemic lupus erythematosus (SLE) activity, a chronic and inflammatory autoimmune disease, on the sinusoidal uptake transporter OATP1B1 using atorvastatin (ATV) as a probe drug. | Atorvastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 3 | In conclusion, uncontrolled SLE increased the systemic exposure to both ATV and ATV-lactone, inferring inhibition of OATP1B1 activity, once in vivo CYP3A4 activity assessed by oral clearance of MDZ was unaltered. | Atorvastatin | solute carrier organic anion transporter family member 1B1 | Homo sapiens |