Pub. Date : 2020 Oct
PMID : 32459872
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pharmacokinetic Drug Interactions of an Orally Available TRH Analog (Rovatirelin) With a CYP3A4/5 and P-Glycoprotein Inhibitor (Itraconazole). | Itraconazole | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Itraconazole has the potential to inhibit drug transport via intestinal P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP); therefore, substrate assessments of rovatirelin for the 2 transporters were evaluated using Caco-2 cell monolayers. | Itraconazole | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Itraconazole has the potential to inhibit drug transport via intestinal P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP); therefore, substrate assessments of rovatirelin for the 2 transporters were evaluated using Caco-2 cell monolayers. | Itraconazole | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | The current study shows that itraconazole"s effect on rovatirelin pharmacokinetics is mediated through inhibition of CYP3A4/5 and intestinal P-gp. | Itraconazole | ATP binding cassette subfamily B member 1 | Homo sapiens |