Pub. Date : 2020 May 21
PMID : 32455838
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Two separate but somewhat overlapping models-the diacylglycerol (DAG) model and the ceramide model-have emerged to explain the development of insulin resistance. | Ceramides | insulin | Homo sapiens |
| 2 | Studies have shown that lipid deposition in tissues such as muscle and liver inhibit insulin signaling via the toxic molecules DAG and ceramide. | Ceramides | insulin | Homo sapiens |
| 3 | Ceramides are sphingolipids with variable acyl group chain length and activate protein phosphatase 2A that dephosphorylates Akt to block insulin signaling. | Ceramides | insulin | Homo sapiens |