Title : Long-term arsenite exposure decreases autophagy by increased release of Nrf2 in transformed human keratinocytes.

Pub. Date : 2020 Sep 10

PMID : 32450402






2 Functional Relationships(s)
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1 Downstream mTOR and Bcl2 were upregulated by Nrf2 signaling, inhibiting autophagy initiation in arsenite-exposed HaCaT cells. arsenite BCL2 apoptosis regulator Homo sapiens
2 In conclusion, our data suggest that long-term exposure to arsenite promotes Nrf2 upregulation via the PI3K/Akt pathway and, along with upregulation of downstream mTOR and Bcl2, contributes to autophagy dysfunction in transformed HaCaT cells. arsenite BCL2 apoptosis regulator Homo sapiens