Title : Protective Effects of Antioxidant Polyphenols against Hyperglycemia-Mediated Alterations in Cerebral Endothelial Cells and a Mouse Stroke Model.

Pub. Date : 2020 Jul

PMID : 32447828






2 Functional Relationships(s)
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1 In vitro, polyphenols improved ROS levels, Cu/ZnSOD activity and both Nox4 and Nrf2 gene expression deregulated by high glucose. Polyphenols nuclear factor, erythroid derived 2, like 2 Mus musculus
2 Polyphenols reduced Nrf2 nuclear translocation, and counteracted NFkB pathway activation, IL-6 secretion and the altered production of vasoactive markers mediated by high glucose. Polyphenols nuclear factor, erythroid derived 2, like 2 Mus musculus