Pub. Date : 2020 Jun
PMID : 32439863
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we found that EGFR induced PPARdelta phosphorylation at tyrosine-108 leading to increased binding of LC3 to PPARdelta by its LIR (LC3 interacting region) motif, consequently, inhibited autophagic flux. | Tyrosine | epidermal growth factor receptor | Homo sapiens |
| 2 | Furthermore, EGFR-mediated PPARdelta phosphorylation at tyrosine-108 led to autophagy inhibition and tumor growth. | Tyrosine | epidermal growth factor receptor | Homo sapiens |