Title : AXL Mediates Cetuximab and Radiation Resistance Through Tyrosine 821 and the c-ABL Kinase Pathway in Head and Neck Cancer.

Pub. Date : 2020 Aug 15

PMID : 32439698






3 Functional Relationships(s)
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1 RPPA analysis revealed that such resistance emanates from signaling of tyrosine 821 of AXL via the tyrosine kinase c-ABL. Tyrosine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
2 CONCLUSIONS: Collectively, the studies presented herein suggest that tyrosine 821 of AXL mediates resistance to cetuximab by activation of c-ABL kinase in HNSCC and that targeting of both EGFR and c-ABL leads to a robust anti-tumor response. Tyrosine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
3 CONCLUSIONS: Collectively, the studies presented herein suggest that tyrosine 821 of AXL mediates resistance to cetuximab by activation of c-ABL kinase in HNSCC and that targeting of both EGFR and c-ABL leads to a robust anti-tumor response. Tyrosine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens