Title : A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy.

Pub. Date : 2020 Jul 6

PMID : 32437499






1 Functional Relationships(s)
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1 Synthesis of the phosphoinositide PI(3)P by the autophagic class III phosphatidylinositol-3 kinase complex I (PI3KC3-C1) and conjugation of ATG8/LC3 proteins to phagophore membranes by the ATG12-ATG5-ATG16L1 (E3) complex are two critical steps in autophagosome biogenesis, connected by WIPI2. Phosphatidylinositols autophagy related 5 Homo sapiens