Protein Name autophagy related 5
Organism Homo sapiens
Gene ID 9474
Gene Symbol

ATG5

UniProt Q9H1Y0 (ATG5_HUMAN), A9UGY9 (A9UGY9_HUMAN), Q7Z3H3 (Q7Z3H3_HUMAN)
Relationships Total Number of functionally related compound(s) : 397
Total Number of Articles : 558
Description

autophagy related 5

Gene Summary

The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

synonyms
  • autophagy protein 5
  • APG5 autophagy 5-like
  • ATG5 autophagy related 5 homolog
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Properties