Pub. Date : 2020 Aug
PMID : 32433937
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Midazolam contributes to neuroprotection against hypoxia/reoxygenation-induced brain injury in neonatal rats via regulation of EAAT2. | Midazolam | solute carrier family 1 member 2 | Rattus norvegicus |
| 2 | The present study aimed to detect the role of EAAT2 in the neuroprotective effect of midazolam in neonatal rat brain subjected to H/R. | Midazolam | solute carrier family 1 member 2 | Rattus norvegicus |
| 3 | Pretreatment with midazolam reversed H/R-induced apoptosis and downregulation of EAAT2 mRNA and protein expression in the hippocampus. | Midazolam | solute carrier family 1 member 2 | Rattus norvegicus |
| 4 | Pretreatment with dihydrokainic acid (a selective inhibitor of EAAT2) exacerbated apoptosis, and thus inhibited the neuroprotective effect of midazolam against H/R injury. | Midazolam | solute carrier family 1 member 2 | Rattus norvegicus |
| 5 | We demonstrated for the first time that dysregulation of EAAT2 expression may be related to the neural injury induced by H/R in rat pups, and pretreatment with midazolam attenuated apoptosis and improved learning and memory partly due to regulating EAAT2 expression. | Midazolam | solute carrier family 1 member 2 | Rattus norvegicus |
| 6 | We demonstrated for the first time that dysregulation of EAAT2 expression may be related to the neural injury induced by H/R in rat pups, and pretreatment with midazolam attenuated apoptosis and improved learning and memory partly due to regulating EAAT2 expression. | Midazolam | solute carrier family 1 member 2 | Rattus norvegicus |