Pub. Date : 2020 May 19
PMID : 32429997
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: Alterations in estrogen and progesterone signaling, via their respective receptors, estrogen receptor alpha (ERalpha) and progesterone receptor (PR), respectively, are largely involved in the development of breast cancer (BC). | Progesterone | progesterone receptor | Homo sapiens |
| 2 | BACKGROUND: Alterations in estrogen and progesterone signaling, via their respective receptors, estrogen receptor alpha (ERalpha) and progesterone receptor (PR), respectively, are largely involved in the development of breast cancer (BC). | Progesterone | progesterone receptor | Homo sapiens |
| 3 | Moreover, it regulates PR expression and phosphorylation on key residues, impacting the biological effects of progesterone. | Progesterone | progesterone receptor | Homo sapiens |
| 4 | CONCLUSIONS: ERalpha-36 is thus a regulator of PR signaling, interfering with its transcriptional activity and progesterone-induced anti-proliferative effects as well as migratory capacity. | Progesterone | progesterone receptor | Homo sapiens |