Pub. Date : 2021 Mar
PMID : 32426849
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Disulfide-HMGB1 Drives Ischemia-Reperfusion Injury in Human Liver Transplantation. | Disulfides | high mobility group box 1 | Homo sapiens |
| 2 | Portal blood immediately following allograft reperfusion (liver flush, LF) had increased total HMGB1, but only LF from patients with histopathological IRI had increased disulfide-HMGB1 and induced TLR4-dependent TNFalpha production by macrophages. | Disulfides | high mobility group box 1 | Homo sapiens |
| 3 | Disulfide HMGB1 levels increased concomitantly with IRI severity. | Disulfides | high mobility group box 1 | Homo sapiens |
| 4 | IRI+ pre-reperfusion biopsies contained macrophages with hyperacetylated, lysosomal disulfide-HMGB1 that increased post-reperfusion at sites of injury, paralleling increased histone acetyltransferase GTF3C4 and decreased histone deacetylase HDAC5 expression. | Disulfides | high mobility group box 1 | Homo sapiens |
| 5 | Purified disulfide-HMGB1 or IRI+ blood stimulated further production of disulfide-HMGB1 and increased pro-inflammatory molecule and cytokine expression in macrophages via a positive feedback loop. | Disulfides | high mobility group box 1 | Homo sapiens |
| 6 | Purified disulfide-HMGB1 or IRI+ blood stimulated further production of disulfide-HMGB1 and increased pro-inflammatory molecule and cytokine expression in macrophages via a positive feedback loop. | Disulfides | high mobility group box 1 | Homo sapiens |
| 7 | Purified disulfide-HMGB1 or IRI+ blood stimulated further production of disulfide-HMGB1 and increased pro-inflammatory molecule and cytokine expression in macrophages via a positive feedback loop. | Disulfides | high mobility group box 1 | Homo sapiens |
| 8 | Purified disulfide-HMGB1 or IRI+ blood stimulated further production of disulfide-HMGB1 and increased pro-inflammatory molecule and cytokine expression in macrophages via a positive feedback loop. | Disulfides | high mobility group box 1 | Homo sapiens |
| 9 | CONCLUSIONS: These data identify disulfide-HMGB1 as a mechanistic biomarker of, and therapeutic target for, minimizing sterile inflammation during human liver IRI. | Disulfides | high mobility group box 1 | Homo sapiens |