Title : Possible differences in the mechanism of malignant transformation of HaCaT cells by arsenite and its dimethyl metabolites, particularly dimethylthioarsenics.

Pub. Date : 2020 May 6

PMID : 32416464






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 However, the cells exposed to arsenite are transformed by the continuous nuclear translocation of Nrf2 due to oxidative stress, and the persulfide from dimethylthioarsenics may promote Nrf2 by the combination with thiol groups, especially redox control key protein, Keap1, eventually cause nuclear translocation of sustained Nrf2. persulfides NFE2 like bZIP transcription factor 2 Homo sapiens
2 However, the cells exposed to arsenite are transformed by the continuous nuclear translocation of Nrf2 due to oxidative stress, and the persulfide from dimethylthioarsenics may promote Nrf2 by the combination with thiol groups, especially redox control key protein, Keap1, eventually cause nuclear translocation of sustained Nrf2. persulfides NFE2 like bZIP transcription factor 2 Homo sapiens