Title : Therapeutic Potential of Peroxisome Proliferator-Activated Receptor (PPAR) Agonists in Substance Use Disorders: A Synthesis of Preclinical and Human Evidence.

Pub. Date : 2020 May 12

PMID : 32408505






2 Functional Relationships(s)
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1 Robust evidence from animal models suggests that agonists at both the PPAR-alpha and PPAR-gamma isoforms can reduce both positive and negative reinforcing properties of ethanol, nicotine, opioids, and possibly psychostimulants. Nicotine peroxisome proliferator activated receptor gamma Homo sapiens
2 The PPAR-gamma agonist pioglitazone showed some promise in reducing heroin, nicotine, and cocaine craving in two human laboratory studies and one pilot trial, yet other outcomes were unaffected. Nicotine peroxisome proliferator activated receptor gamma Homo sapiens