Title : Tob2 phosphorylation regulates global mRNA turnover to reshape transcriptome and impact cell proliferation.

Pub. Date : 2020 Sep

PMID : 32404348






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In this study, we found that c-Jun amino-terminal kinase (JNK) increases phosphorylation of Tob2 at many Ser/Thr sites in the intrinsically disordered region (IDR) that contains two separate PABP-interacting PAM2 motifs. Serine mitogen-activated protein kinase 8 Homo sapiens
2 In this study, we found that c-Jun amino-terminal kinase (JNK) increases phosphorylation of Tob2 at many Ser/Thr sites in the intrinsically disordered region (IDR) that contains two separate PABP-interacting PAM2 motifs. Serine mitogen-activated protein kinase 8 Homo sapiens
3 In contrast, JNK-independent phosphorylation of Tob2 at serine 254 (S254) greatly enhances Tob2 interaction with PABP and its ability to promote deadenylation. Serine mitogen-activated protein kinase 8 Homo sapiens