Pub. Date : 2020 Jun
PMID : 32399817
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tannic Acid Provides Neuroprotective Effects Against Traumatic Brain Injury Through the PGC-1alpha/Nrf2/HO-1 Pathway. | Tannins | heme oxygenase 1 | Rattus norvegicus |
| 2 | Moreover, TA treatment effectively upregulated the protein expression of peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1alpha) and nuclear factor-E2-related factor-2 (Nrf2) as well as mitochondrial transcription factor A and heme oxygenase-1 (HO-1) following TBI. | Tannins | heme oxygenase 1 | Rattus norvegicus |
| 3 | Moreover, TA treatment effectively upregulated the protein expression of peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1alpha) and nuclear factor-E2-related factor-2 (Nrf2) as well as mitochondrial transcription factor A and heme oxygenase-1 (HO-1) following TBI. | Tannins | heme oxygenase 1 | Rattus norvegicus |
| 4 | Overall, our results suggest that TA effectively ameliorates the behavioral alterations, oxidative damage, mitochondrial impairment, and inflammation against TBI that may be attributed to activation of PGC-1alpha/Nrf-2/HO-1 signaling pathway. | Tannins | heme oxygenase 1 | Rattus norvegicus |