Title : Extracellular Signal-Regulated Kinases Mediate an Autoregulation of GABAB-Receptor-Activated Whole-Cell Current in Locus Coeruleus Neurons.

Pub. Date : 2020 May 12

PMID : 32398643






3 Functional Relationships(s)
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1 In this study, we further showed using western blot analysis that the activation of GABABRs with baclofen could increase the level of phosphorylated extracellular signal-regulated kinase 1 (ERK1) in LC tissue. gababrs mitogen-activated protein kinase 1 Homo sapiens
2 In this study, we further showed using western blot analysis that the activation of GABABRs with baclofen could increase the level of phosphorylated extracellular signal-regulated kinase 1 (ERK1) in LC tissue. gababrs mitogen-activated protein kinase 1 Homo sapiens
3 These results suggest a new role of GABABRs in mediating ERK1-dependent autoregulation of the stability of GABABR-activated whole-cell current, in addition to its well-known effect on gated potassium channels, to cause a tonic current in LC neurons. gababrs mitogen-activated protein kinase 1 Homo sapiens